A flow perfusion bioreactor with controlled mechanical stimulation: Application in cartilage tissue engineering and beyond
نویسندگان
چکیده
منابع مشابه
A dual flow bioreactor with controlled mechanical stimulation for cartilage tissue engineering.
In cartilage, tissue engineering bioreactors can create a controlled environment to study chondrocyte behavior under mechanical stimulation or produce chondrogenic grafts of clinically relevant size. Here we present a novel bioreactor that combines mechanical stimulation with a two compartment system through which nutrients can be supplied solely by diffusion from opposite sides of a tissue-eng...
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Skeletal development is a multistep process that involves the complex interplay of multiple cell types at different stages of development. Besides biochemical and physical cues, oxygen tension also plays a pivotal role in influencing cell fate during skeletal development. At physiological conditions, bone cells generally reside in a relatively oxygenated environment whereas chondrocytes reside ...
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Nutrient transport limitation remains a fundamental issue for in vitro culture of engineered tissues. In this study, perfusion bioreactor configurations were investigated to provide uniform delivery of oxygen to media equivalents (MEs) being developed as the basis for tissue-engineered arteries. Bioreactor configurations were developed to evaluate oxygen delivery associated with complete transm...
متن کاملDesign of a flow perfusion bioreactor system for bone tissue-engineering applications.
Several different bioreactors have been investigated for tissue-engineering applications. Among these bioreactors are the spinner flask and the rotating wall vessel reactor. In addition, a new type of culture system has been developed and investigated, the flow perfusion culture bioreactor. Flow perfusion culture offers several advantages, notably the ability to mitigate both external and inter...
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ژورنال
عنوان ژورنال: Journal of Stem Cell Therapy and Transplantation
سال: 2018
ISSN: 2577-1469
DOI: 10.29328/journal.jsctt.1001011